Bettina's Real INBRIJA^® Story

[Bettina is sitting down talking to the camera]

Bettina, Living with Parkinson's Since 2007

Hello, I'm Bettina, and I'm 48 years old and I've had Parkinson's for 14 years, although you probably couldn't tell.

[Photo of Bettina's dog Blanche sitting in backseat of biplane is shown]

I live with my dog Blanche in Connecticut. She's a pit bull mix. She's a wonderful dog.

[Bettina is sitting in chair and talking to camera]

I grew up in the aviation business. I've been I was a journalist for many years specializing in aerospace and aviation.

[Photo of Bettina holding a camera at an Air Show is shown]

My dad was in the business and I just worshiped him.

[Photo of Bettina's dad holder her as a baby is shown]

[Bettina is sitting in chair and talking to camera]

He took me to all these shows all over the world, air shows, and I made it then my business. I wrote for Aviation Week magazine, then I transitioned into working for PR, covering Rotary Wings or helicopter programs for a corporation. And then finally I moved to a company doing marketing for their federal and defense business.

[Photo of Bettina holding a microphone while working in PR is shown]
[Photo of Bettina's standing next to a helicopter is shown]
[Bettina is sitting in a chair and talking to camera]

It was a long road to my Parkinson's diagnosis.

[Photo of Bettina standing in front of canyons]
[Bettina is sitting in a chair and talking to camera]

I was 34 years old, and I noticed a twitch, a spasm in my finger that wouldn't go away. So, I thought, well, maybe it's the mouse I'm using, so I went to see my doctor, who said, well, maybe it's carpal tunnel. So, he referred me to an orthopedist and the orthopedist referred me to his buddy, the neurologist, who said, there's no way you can have Parkinson's, you're too young. So, he then sent me to an ophthalmologist. And finally, my acupuncturist at the time told me I needed to press for a diagnosis, and she advised me to go to the National Institutes of Health, where finally, a few months later, I was diagnosed with Parkinson's disease.

[Bettina is sitting at a desk working]

Parkinson's has had the most profound effect on my work life. I've had to make adjustments throughout the years. In the beginning you couldn't even tell I had Parkinson's and I was feeling pretty good most of the time, so I didn't change anything.

[Photo of Bettina in a helicopter is shown]
[Back of Bettina sitting in a chair talking to the camera]

And then through the years, especially as a journalist, I traveled 180 days a year, which was just way too much. I've been very, very lucky. I count my lucky stars every day that any job I've had, I've always been, people have always known that I had Parkinson's, I never had to hide it. And for that reason, I think people have always been very generous with their support, with their help.

[Photos of Bettina with friends and family are shown]
[Cut back to Bettina sitting in a chair talking to the camera]

The friends I have I rely on is such a wonderful community of friends and family. And in the past few years also, I've developed very close friendships with newly diagnosed Parkinson's patients. As someone who's had it for 14 years, I'm kind of the godfather of Parkinson's among the women that I know and to form some lasting friendships and support there as well.

[Photo of Bettina at a Parkinson's walk]

Even though I take carbidopa/levodopa for Parkinson's, there are times of day when it doesn't always works 100 percent. And those are considered my off periods. And for me, they're very marked. They're not the same for everybody. For me, you can really tell when I'm on like now or when I'm off, like shufflilng and slow. I get dystonia, so real stiff and tremors, the tremors are the worst, they just make functioning very difficult for me. I typically experience a return of symptoms twice a day, late in the morning and early evening, late afternoon, especially if I've had a long day. Because I know I was experiencing a return of symptoms, I did some research and discovered INBRIJA and talked to my doctor. He asked me to come in and have an appointment to discuss taking it.

INBRIJA^® (levodopa inhalation powder, 42 mg capsules)

INBRIJA is a prescription medicine used when needed for OFF episodes in adults with Parkinson's treated with regular carbidopa/levodopa medicine.

Do not use INBRIJA if you take or have taken a nonselective monoamine oxidase inhibitor such as phenelzine or tranylcypromine within the last 2 weeks.

I always encourage others to take an active role in managing their condition. There's always something you can do, which is why my doctor recommended INBRIJA. Once I use INBRIJA, I notice it begins to work for me in about 15 minutes.

In a large clinical trial, INBRIJA started improving motor symptoms in as soon as 10 minutes. However, individual results may vary.

[Bettina opening the inhaler, then opening a blister pack]

As we are recording this, I'm actually heading into an off period, so I'm going to go take my INBRIJA.

Please see accompanying Instructions For Use at www.INBRIJALabel.com

[Bettina loading the inhaler with a capsule, then putting the top on the inhaler]

INBRIJA is a prescription medicine used when needed for OFF episodes in adults with Parkinson's treated with regular carbidopa/levodopa medicine.

[Bettina taking a long slow inhalation of a single dose of INBRIJA]

INBRIJA does not replace regular carbidopa/levodopa medicine.

INBRIJA does not replace regular carbidopa/levodopa medicine. Do not use INBRIJA if you take or have taken a nonselective monoamine oxidase inhibitor such as phenelzine or tranylcypromine within the last two weeks.

[Bettina taking a sip of water following the inhalation of INBRIJA]

Do not orally inhale more than 1 dose (2 capsules) for any OFF period. Do not take more than 5 doses (10 capsules) in a day.

[Bettina is sitting in front of books, talking to the camera]

Now I use INBRIJA as needed normally a couple of times a day when I feel my Parkinson's symptoms start to return.

[Bettina's dog Blanche coming down the stairs]
[Cut back to Bettina sitting in a chair and talking to camera]

Please see additional Important Safety Information at the end of this video.

When I'm inhaling, I always make sure to hear and feel the capsule whirl.

[Bettina putting the leash on Blanche and going outside for a walk]

I found the right speed for me to inhale. Not too fast, not too slow.

[Bettina and Blanche walking down the front walkway]

Doing that helps me lessen the cough I experience. Sometimes I experience some mild nausea.

[Bettina and Blanche playing in the yards]

If you or a loved one with Parkinson's taking carbidopa/levodopa, think you might be experiencing off periods, it's a good idea to speak with your movement disorders doctor or your neurologist to determine if adding INBRIJA might help you.

[Shows video of Bettina and Blanche coming back inside and playing in the living room]

Whenever I need it, morning, noon or night INBRIJA is there to help me when my Parkinson's symptoms return.

[Bettina is sitting in a chair talking to the camera]

Just because you have Parkinson's and it's a chronic condition doesn't mean you have to feel bad all the time.

[Blanche jumps up on the couch next to Bettina, then the video cuts to Bettina playing the piano, then back to Bettina sitting in a chair talking to the camera]

You're going to be up days down days, up months, down months. You can advocate for yourself, find the medication that works for you and with INBRIJA I can go out now for like a longer time. I can take pictures; I can do stuff I couldn't do. I can play the piano and that's; sorry, that's what it means to me. So, thank you.

Before using INBRIJA, tell your healthcare provider about your medical conditions, including:

• asthma, chronic obstructive pulmonary disease or COPD, or any chronic lung disease
• daytime sleepiness, sleep disorders, sleepiness or drowsiness without warning, or use of medicine that increases sleepiness, including antidepressants or antipsychotics
• dizziness, nausea, sweating, or fainting when standing up
• abnormal movement or dyskinesia
• mental health problems such as hallucinations or psychosis
• uncontrollable urges like gambling, sexual urges, spending money, or binge eating
• glaucoma
• pregnancy or plans to become pregnant. It is unknown if INBRIJA will harm an unborn baby.
• breastfeeding or plans to breastfeed. Levodopa can pass into breastmilk and it is unknown if it can harm the baby.

Tell your healthcare provider if you take:

• MAO-B inhibitors
• dopamine (D2) antagonists (including phenothiazines, butyrophenones, risperidone and metoclopramide)
• isoniazid
• iron salts or multivitamins that contain iron salts

Do not drive, operate machinery, or do other activities until you know how INBRIJA affects you. Sleepiness and falling asleep suddenly can happen as late as a year after treatment is started.

Tell your healthcare provider if you experience the following side effects:

• falling asleep during normal daily activities with or without warning. If you become drowsy, do not drive or do activities where you need to be alert. Chances of falling asleep during normal activities increases if you take medicine that cause sleepiness.
• withdrawal-emergent hyperpyrexia and confusion with fever, stiff muscles, or changes in breathing and heartbeat. If you suddenly stop using INBRIJA or carbidopa/levodopa, or suddenly lower your dose of carbidopa/levodopa.
• low blood pressure when standing up (that may be with dizziness, fainting, nausea, and sweating). Get up slowly after sitting or lying down.
• hallucinations and other psychosis – INBRIJA may cause or worsen seeing, hearing or believing things that are not real; confusion, disorientation, or disorganized thinking; trouble sleeping; dreaming a lot; being overly suspicious or feeling people want to harm you; acting aggressive; and feeling agitated or restless.
• unusual uncontrollable urges such as gambling, binge eating, shopping, and sexual urges has occurred in some people using medicine like INBRIJA.
• uncontrolled, sudden body movements or dyskinesia may be caused or worsened by INBRIJA. INBRIJA may need to be stopped or other Parkinson’s medicines may need to be changed.
• bronchospasm – people with asthma, COPD, or other lung diseases may wheeze or have difficulty breathing after inhaling INBRIJA. If this occurs, stop taking INBRIJA and seek immediate medical attention.
• increased eye pressure in patients with glaucoma. Your healthcare provider should monitor this.
• changes in certain lab values including liver tests

The most common side effects of INBRIJA are cough, upper respiratory tract infection, nausea, and change in the color of saliva or spit.

Do not orally inhale more than 1 dose, that's 2 capsules, for any OFF period. Do not take more than 5 doses, that's 10 capsules, in a day. Please ask your doctor about whether INBRIJA may be right for you.

Please see the Patient Information Leaflet and Instructions For Use at InbrijaLabel.com or scan the QR code provided.

[Bettina sitting in chair talking to the camera]

Thank you for listening to my story. And if you want to hear about other people's Parkinson's journeys, visit Inbrija.com.

ACORDA THERAPEUTICS, the stylized ACORDA THERAPEUTICS logo, INBRIJA and the INBRIJA logo are all trademarks of Acorda Therapeutics, Inc. © 2021 Acorda Therapeutics, Inc. All rights reserved. 03/21 INB10357

[END OF TRANSCRIPT]

04/21 INB10377